Delta Air Lines is canceling about 350 flights due to the storm set to hit Atlanta, home of its largest hub.
Atlanta-based Delta said the cancellations affect flights scheduled for Friday evening and Saturday. And more flight cancellations are possible.
About 4 inches of snow are expected at Hartsfield-Jackson International Airport, according to Delta.
The cancellations are "an effort to minimize the storm's effect on operations at the world's busiest hub," according to Delta.
Those whose flights are cancelled or significantly delayed are entitled to a refund.
Delta is waiving certain change fees for travelers who want to change their plans to avoid the effects of the storm and the risk of their flight being cancelled.